Table 1.

Chemotherapeutic drugs implicated in CIPN.

Type of drug	Example	Mechanisms of drug action in treating cancer	Type of neuron affected
Platinum agents	Cisplatin Oxaliplatin	Bind to DNA, cell cycle arrest and apoptosis	Sensory
Taxane	Paclitaxel	Inhibit microtubule depolymerization, mitotic arrest	Sensory
Vinca alkaloid	Vincristine	Inhibit microtubule polymerization, mitotic arrest	Sensory, as well as motor and autonomic
Proteasome inhibitor	Bortezomib	Inhibit proteasome degradation, cycle arrest; enhance microtubule polymerization	Sensory