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. 2017 Sep 4;7:10346. doi: 10.1038/s41598-017-10842-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two loci dynamics before and after Zeocin treatment. (A) Two tagged loci (a and b, circles) separated by a genomic distance Δ_ab = 50 kbp. When the loci are within a distance ε μm (red circle), they are considered to encounter for computing the FET, and above ε (lower) for the FDT. We analyzed the untreated and Zeocin treated cases, where Zeocin induces DNA damages (red X) at random positions along the DNA. (B) The FET (left column) and FDT (right) empirical distributions in the untreated (upper) and Zeocin treated (lower) cases, fitted by a exp (−λt) (red curves), where the reciprocal of λ is the MFET and MFDT in their respective cases. R ² values from the fit are reported in each box. (C) The MFET (left) is plotted with respect to the encounter distance ε for the untreated (blue) and Zeocin treated (orange) cases. For the MFET (left), both curves are at a plateau of at 0.5 s (phase 2) above ε > 0.25 μm. The MFDT (right) increase with ε from 0.2 s at ε = 0.15 μm to 0.5 s at ε = 0.5 μm for the untreated (blue) and Zeocin treated (orange) case.