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. 2017 Sep 4;7:10355. doi: 10.1038/s41598-017-09872-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Light microphotograph (A) with haematoxylin and eosin (HE) stain showing histologic evaluation of rabbit bladder (Top to base: umbrella, intermediate and basal cells; arrows show the typical “dome-shaped” apical cells). Normalized expression value 2^−ΔΔCt (mean ± standard error) (B) of CD44, RHAMM and ICAM-1 in bladder tissues incubated with HA-AuNP and CS-AuNP (left box for each type of receptor) and control bladder tissues incubated with BSA-AuNPs solution (dashed line).