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. 2017 Sep 4;7:10313. doi: 10.1038/s41598-017-10875-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p17-injected mice showed significant deterioration of behavior compared to control mice. (a) p17-injected mice (p17) showed lower fine motor coordination as they travelled a significantly shorter distance in the wire hang test in respect to control animals injected with vehicle (Vehicle). (b–f) p17-injected mice showed behavioral and psychological symptoms of dementia–like, namely neophobia, indicated by (b) lower corner explorations and (c) lower number of rearings, (d) lower exploratory curiosity with higher latency to explore the whole 4 holes in the Boissier’s hole-board test, and (e) higher anxiety indicated by increased latency to enter to the lit compartment and (f) lower number of explorations in the dark and light box test, than Vehicle animals. Mean ± SE (n = 8 mice/group). *P < 0.05 and **P < 0.01 vs. Vehicle, unpaired Student’s t-test.