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. 2017 Sep 4;7:10313. doi: 10.1038/s41598-017-10875-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological localization of p17 in the mouse hippocampus and local cortical regions. Representative immunohistochemistry of brain sections showing the staining for (a) p17 (N-DAB stain, gray-black) into the CA1 region localized to cortical microvessels and (b) CD105 (DAB)-positively stained vessels in the same location in a serial section. (c) P17 was observed in hippocampal neurons adjacent to the injection point (inset scale bar = 10 µm), (d) in the same region as phosphorylated tau (p-tau, DAB) (inset scale bar = 10 µm). (e) P17 was found to be expressed consistently within cortical neurons, some of which (f) were also p-tau-positive. (g) No staining was observed in none-injected controls. (h,i) P-tau positivity in sham-injected 3xTg mouse. Scale bars (a–h) = 50 µm, (i) = 10 µm. Images show representative staining results from one or more of six animals in each grouping where sectioning throughout the whole bregma was carried out. See Supplementary Information for immunofluorecence and double immunohistochemistry staining patterns as well as primary antibody-negative controls.