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. 2017 Sep 4;7:10314. doi: 10.1038/s41598-017-10746-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term consequences of orchiectomy. (a) Two cohorts of male Foxn1:eGFP transgenic mice were castrated at either 2 or 6 months of age; their thymopoietic parameters were examined at approximately 12 months of age (the means and s.e.m. of analysis time points are indicated) and compared to those of a male control group (combined cohorts of untreated and sham-operated males, which did not differ in the parameters studied here), and of female mice. (b) Number of thymic epithelial cells (TECs). (c) Number of CD45⁺ thymocytes. (d) Thymopoietic indices, calculated as thymocyte/TEC ratios. (e) Fraction of eGFP⁺ cells as a measure of Foxn1-expression in the thymic epithelium. The total numbers (mean values) of eGFP⁺ TECs is as follows. Males: 7,200 cells; cohort 1: 3,200 cells; cohort 2: 5,000 cells; females: 3,000 cells. (f) Linear relationship between the thymopoietic indices and the fraction of eGFP⁺ TECs. Means ± s.e.m.