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. 2017 Sep 4;7:10394. doi: 10.1038/s41598-017-10740-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synteny analyses depict origin of different HSP47/SERPINH1 genes. (A) Orthology is shared by tetrapod HSP47/SERPINH1 gene and ray-finned specific HSP47_1/SERPINH1 gene and selected ray-finned fishes have intron gain. Tetrapod HSP47/SERPINH1 shares loci with ray-finned specific HSP47_1. HSP47_1 locus is conserved in different ray-finned fishes as shown in the red box, but not all ray-finned fishes intron gain and fishes with no intron gain are shown in green box. (B) HSP47_2 is originated by recent duplication of HSP47_1. (C) Locus of HSP47_3 is distinct with only few conserved marker genes. + = presence of two additional introns at the positions 36b and 102b; X = Gene is either partial or lost.