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. 2017 Sep 4;7:10394. doi: 10.1038/s41598-017-10740-0

Table 2.

Summary of sequence conservation on the secondary structural element levels of HSP47/SERPINH1 proteins.

Structural Components Sequence Conservation Status of 51 conserved amino acids $
90–100 70–89 50–69
N-terminal segment 0 8 9
hA 3 4 7 F33 !
s6B 1 0 2 N49 S53
hB 3 4 4 P54 S56 L61 G67
hC 2 3 2 T72 L80
hD 2 5 5
s2A 0 6 3
hE 1 5 4 F130
s1A 0 1 2
hF 3 4 9 F147 I157 N158 V161 T165
Loop between hF/s3A 1 1 2 I169 T180
s3A 5 4 8 L184 % N186 F190 K191 G192
hF1 0 2 1
s4C 2 0 3 F198 T203 F208
s3C 5 4 2 V218 M220 M221
s1B 1 0 1
s2B 1 2 1 Y244
s3B 0 1 1 L254 P255
hG 2 4 1
hH 1 1 2
s2C 3 2 1
s6A 0 1 2 P289 K290
hI 4 0 2 L299 L303 G307
hI1 0 2 0
Loop between hI/s5A 6 6 6 F312 A316 L327
s5A 2 3 1 H334 E342
s4A (RCL) 3 4 10 G344 A347
s1C 3 0 0
s4B 2 3 2 P369 F370
s5B 2 2 5 L383 F384 G386
C terminal end 4 1 5 P391

$As proposed by Irving et al. (2000). !Bold – Missing.

%Underscore – Partially present (<50% of HSP47).