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. 2017 Sep 4;7:8416. doi: 10.1038/s41598-017-08468-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplots of the F_st values of our WES data, according to MAFs of variants. The percentages of the variants which have the range of MAF over the number of all the variants in WES data are shown in x axis with parenthesis; the red line represents F_st cut-off 0.25 according to Wright’s F_st criteria²³. Cardoso, et al.²³ and Strauss, et al.²⁴ defined a gene with PD if it contains at least one Single Nucleotide Polymorphism (SNP) with F_st value greater than 0.25.