Table 3.
10 genes from PDRC tests, using ‘all’ or ‘rare/less-common’ variant selection strategies.
| Gene | PDRC statistics (all) | PDRC statistics (rare/less common) | No. of variant | Fst | |||||
|---|---|---|---|---|---|---|---|---|---|
| Weight:1 | Weight: 1/MAF | Weight:1/MAF2 | Weight:1 | Weight:1/MAF | Weight:1/MAF2 | Common | Rare | Max. | |
| DPYD | 685.41 | 129.22 | 62.52 | 1660.63 | 131.13 | 62.52 | 8 | 365 | 0.0731 |
| F5 | 5561.83 | 148.38 | 83.68 | 5766.33 | 149.95 | 83.68 | 33 | 543 | 0.4027 |
| MTHFR | 1752.40 | 117.12 | 52.88 | 2814.08 | 114.40 | 52.88 | 10 | 262 | 0.3000 |
| SCN5A | 5608.12 | 148.77 | 65.16 | 14227.78 | 149.18 | 65.16 | 6 | 614 | 0.2084 |
| CYP3A4 | 13393.42 | 13.15 | 7.88 | 304.07 | 12.15 | 7.88 | 2 | 160 | 0.4819 |
| CYP3A5 | 8674.38 | 51.27 | 15.36 | 5369.90 | 50.29 | 15.36 | 1 | 165 | 0.2125 |
| EGFR | 40.72 | 107.68 | 53.18 | 6729.38 | 108.06 | 53.18 | 11 | 448 | 0.1594 |
| CYP2E1 | 18902.68 | 68.42 | 24.36 | 9627.48 | 65.97 | 24.36 | 3 | 177 | 0.2128 |
| ACE | 3382.44 | 154.36 | 53.90 | 16909.20 | 154.33 | 53.90 | 9 | 585 | 0.1887 |
| CYP2B6 | 96.18 | 204.00 | 66.52 | 1358.99 | 204.16 | 66.52 | 2 | 228 | 0.0728 |
Data are PDRC statistics yielded from the ‘all’ and ‘rare/less common’ strategies. Numbers of common and rare variants in each selected gene are described. Max. Fst is the maximal Fst value estimated from variants of each gene.