Table 4.
Nine genes from PDRC tests, using ‘protein-altering’ variant selection strategy.
| Gene Sym | PDRC statistics (protein-altering) | No. of variant | Fst | ||||
|---|---|---|---|---|---|---|---|
| Weight:1 | Weight:1/MAF | Weight:1/MAF2 | Non Protein altering | Protein altering | Protein altering common | Max. | |
| DPYD | 724.50 | 5.32 | 32.22 | 229 | 144 | 3 | 0.0731 |
| F5 | 2280.62 | 0.90 | 43.78 | 271 | 305 | 13 | 0.4027 |
| MTHFR | 958.49 | 4.22 | 32.22 | 181 | 91 | 3 | 0.3000 |
| ADH1B | 8207.13 | 7.33 | 2.38 | 78 | 39 | 1 | 0.5591 |
| EGFR | 970.60 | 17.55 | 30.41 | 323 | 136 | 1 | 0.1594 |
| CYP2E1 | 2818.22 | 51.69 | 7.73 | 113 | 67 | 0 | 0.2128 |
| ACE | 6183.58 | 10.44 | 20.50 | 332 | 262 | 0 | 0.1887 |
| BRCA1 | 1403.64 | 20.15 | 29.45 | 248 | 244 | 3 | 0.1377 |
| CYP2B6 | 968.54 | 20.62 | 31.96 | 115 | 115 | 1 | 0.0728 |
Data are PDRC statistics yielded from the ‘protein altering’ strategy. Numbers of protein-altering and common & protein-altering variant in each selected gene are described. Max. Here, Fst is the maximal Fst value estimated from the variants of each gene.