Table 2. Effect size (with 95% confidence interval) in several sexual parameters across randomized controlled trials evaluating the effect of testosterone treatment vs. placebo.
Sexual parameter | No. of trials included | No. of patients included | Outcome |
---|---|---|---|
Erectile function component | |||
Overall erectile function componenta | 24 | 1,473 | 0.82 [0.47~1.17]* |
Overall sexual-related function componentb | 19 | 1,341 | 0.75 [0.37~1.12]** |
Sleep-related erections | 10 | 436 | 0.87 [0.47~1.27]** |
Libido component | |||
Overall libido component | 17 | 1,111 | 0.81 [0.47~1.17]** |
Orgasm component | |||
Overall orgasmic component | 10 | 677 | 0.68 [0.34~1.02]** |
Other sexual parameters | |||
Frequency of intercourse | 10 | 327 | 0.75 [0.33~1.16]** |
Overall sexual satisfaction | 9 | 618 | 0.80 [0.41~1.20]** |
Overall sexual function | 10 | 990 | 0.67 [0.22~1.12]** |
*p<0.001, **p<0.0001. aIncluding coital and non coital erections; bOnly coital erections considered.
Adapted from Corona G et al (J Sex Med 2014;11:1577-92) [26].