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. 2017 Sep 4;7:10334. doi: 10.1038/s41598-017-10509-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Joint swelling and histopathological scores in AIA in IL-17AKO mice after sympathectomy. (a) Reduction of joint swelling by sympathectomy (n = 6 per group). (b) Reduction of arthritis score in acute AIA after sympathectomy (n = 6 per group). (c) At day 21 of AIA the differences between sympathectomised and non-sympathectomised mice disappeared (n = 6 per group). (d) Typical histology after H&E staining at day 2 of AIA from IL-17AKO mice. AIA controls (left side) show stronger signs of inflammation (infiltration of immune cells, hyperplasia of synovial lining cells and surface defects of cartilage and bone) than sympathectomised mice. M, meniscus; T, tibia; SL, synovial layer. Magnification 100x. Values are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 (two-tailed Student’s t-test).