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. 2017 Sep 4;7:10334. doi: 10.1038/s41598-017-10509-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of IL-17A on excitability and on TTX-resistant and TTX-sensitive Na⁺ currents in isolated and cultured DRG neurones. (a) Testing of the excitability of a neurone using a ramp-shaped current injection protocol. After application of IL-17A the first action potential appeared at a shorter latency (indicating that less current was necessary) and more action potentials were elicited during the ramp. (b) top: voltage-clamp recording from a control DRG neurone showing no increase of TTX-R Na⁺ currents between 5 min (5′, top, left) and 9 min (9′, top, right), bottom: voltage-clamp recording from another neurone showing an increase of TTX-R Na⁺ currents at 5 min after bath application of IL-17A. (c) I/V curve of control neurones (n = 10) at 5 min and at 9–12 min of recording. (d) I/V curve of control neurones (n = 11) before (5 min) and 5–7 min after bath application of IL-17A. (e) Normalised peak conductance (G/G_max, open symbols) and steady-state inactivation (I/I_max, filled symbols) before (5 min) and 5–7 min after bath application of IL-17A.