. 2017 Sep 4;7:10349. doi: 10.1038/s41598-017-10386-y

Table 5.

Multivariate analysis of possible risk factors using the Cox logistic regression method.

Characteristics	Relapse-free survival		Overall survival
Characteristics	HR (95% CI)	P value	HR (95% CI)	p value
Recurrent Stages
Advanced stage (rIVA/rIVB/rIVC)	2.58 (1.47~4.54)	0.001	3.92 (2.01~7.64)	< 0.001
Early stage (rI/rII/rIII)	1.0 (reference)	0.001	1.0 (reference)	< 0.001
TILs Foxp3+ lymphocytes
High	1.72 (0.96~3.05)	0.07	1.30 (0.68~2.50)	0.43
Low	1.0 (reference)	0.07	1.0 (reference)	0.43
TILs CD8+ lymphocytes
Low	2.40 (1.37~4.18)	0.002	2.16 (1.14~4.08)	0.02
High	1.0 (reference)	0.002	1.0 (reference)	0.02
Recurrent NPC Galectin-9 expression
High	1.72 (0.96~3.06)	0.07	1.46 (0.78~2.73)	0.23
Low	1.0 (reference)	0.07	1.0 (reference)	0.23

Abbreviation: NPC, nasopharyngeal carcinoma; TILs, tumour-infiltrating lymphocytes, HR: hazard ratio.