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. 2017 Sep 4;7:10396. doi: 10.1038/s41598-017-11220-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spinning disk confocal microscopy images of immunoliposome-treated, primary rat BCECs. Treatment with either OX26 (upper panel) or isotype IgG (lower panel) immunoliposome revealed a clear association between the fluorescently labelled immunoliposomes and the BCECs. Morphologically, the fluorescent signals were either particulate in the periphery of the cells (arrows) or clustered into larger structures in the perinuclear area (asterisks). Counterstaining with LysoTracker revealed that these larger structures were lysosomes that the endocytosed immunoliposomes had been sorted to. The smaller, particulate signal (arrows) did not co-localize with the lysosomes, suggesting these to be newly endocytosed immunoliposomes. Scale bar depicts 10 µm. DAPI: Diamino-phenylindole.