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. 2017 Sep 4;7:10396. doi: 10.1038/s41598-017-11220-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circulation properties of immunoliposomes and free oxaliplatin. Oxaliplatin-loaded immunoliposomes or free oxaliplatin were injected into young rats and allowed to circulate. Blood was sampled at various time points, and the platinum content quantified by ICP-MS. Free oxaliplatin had poor circulation properties with only a very small amount of platinum being present in the systemic circulation after 1 hour. Encapsulation in the immunoliposomes increased the circulation time of the platinum substantially, with indications of isotype IgG immunoliposomes residing the longest in the systemic circulation. Data are presented as mean ± SD (n = 3–5). %ID/g: Percentage of injected dose per gram. OxPt: Oxaliplatin.