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. 2017 Sep 4;7:10396. doi: 10.1038/s41598-017-11220-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biodistribution of oxaliplatin 1 and 24 hours after administration. Oxaliplatin-loaded immunoliposomes or free oxaliplatin were intravenously injected into young rats and allowed to circulate. At the specified time points, the rats were sacrificed and their organs resected to be analyzed for their content of platinum by ICP-MS. (A) After 1 hour, there was a high liver and spleen accumulation of platinum in the groups treated with immunoliposomes, with OX26 immunoliposomes having a very high uptake in the spleen. Free oxaliplatin accumulated more in the kidneys compared to the immunoliposomal formulations, whereas the OX26 immunoliposomes had a high accumulation in the brain compared to free oxaliplatin and isotype IgG immunoliposomes. (B) After 24 hours, there was still high accumulation of immunoliposomes in the liver and spleen, but compared to the early time point, the other peripheral organs (i.e. kidney, lung and heart) showed greater accumulation of immunoliposomes. Data are presented as mean + SEM (n = 4–5). %ID/g: Percentage of injected dose per gram. OxPt: Oxaliplatin.