Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 4;7:10396. doi: 10.1038/s41598-017-11220-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Uptake of oxaliplatin into different brain fractions after capillary depletion. Oxaliplatin-loaded immunoliposomes or free oxaliplatin were injected into young rats and allowed to circulate for the specified number of hours. The rats were sacrificed and their brains homogenized for subsequent capillary depletion. The isolated fractions from the capillary depletion (capillaries or parenchyma) were analysed for their content of platinum by ICP-MS. (A) After 1 hour, there was a pronounced platinum accumulation in the brain capillaries of rats treated with OX26 immunoliposomes as opposed to those treated with isotype IgG immunoliposomes or free oxaliplatin (p < 0.0001). (B) This difference in brain capillary accumulation between the different groups could not be detected after 24 hours (p = 0.3918). (C) After 1 hour, treatment with OX26 immunoliposomes facilitated a higher platinum content in the brain parenchyma compared to treatment with isotype IgG immunoliposomes or free oxaliplatin (p = 0.0002), (D) which seemed to stay residing after 24 hours (p = 0.0025). Data are presented as mean + SEM (n = 4–5), and the p-values depicted were derived from a one-way ANOVA with Tukey’s multiple comparisons post hoc test. %ID/g: Percentage of injected dose per gram. OxPt: Oxaliplatin.