Table 3.
Variable | Univariate analysis |
Multivariate analysis |
|||
---|---|---|---|---|---|
HR | p value | HR | 95% CI | p value | |
Male sex | 1.48 | 0.341 | 2.49 | 0.76–8.83 | 0.159 |
Age, yr | 1.05 | 0.037 | 1.09 | 1.002–1.19 | 0.046 |
BMI, ≥ 25 kg/m2 | 0.38 | 0.056 | 0.65 | 0.58–1.03 | 0.094 |
Duration of diabetes, yr | 0.95 | 0.594 | 0.83 | 0.66–1.05 | 0.113 |
Hypertension, yes | 1.42 | 0.164 | 2.24 | 0.72–1.23 | 0.243 |
SBP, mmHg | 1.21 | 0.142 | 1.34 | 0.82–1.41 | 0.564 |
HbA1c, ≥ 7% | 1.12 | 0.143 | 1.62 | 0.73–1.24 | 0.728 |
Hemoglobin | 0.86 | 0.034 | 0.78 | 0.43–0.92 | 0.125 |
LDL-C, ≥ 100 mg/dL | 1.92 | 0.309 | 1.67 | 0.69–1.84 | 0.384 |
HDL-C, ≤ 40 mg/dL (M), ≤ 50 mg/dL (F) | 1.62 | 0.732 | 1.26 | 0.52–2.85 | 0.826 |
Triglycerides, ≥ 150 mg/dL | 1.62 | 0.522 | 1.33 | 0.91–2.42 | 0.423 |
Total bilirubin | |||||
Q1 | 3.77 | 0.094 | 7.36 | 1.24–35.82 | 0.019 |
Q2 | 2.71 | 0.222 | 5.37 | 0.94–24.32 | 0.060 |
Q3 | 0.85 | 0.872 | 0.95 | 0.35–1.04 | 0.959 |
Q4 | 1.00 | 0.148 | 1.00 | - | 0.040 |
Diabetic retinopathy, yes | 1.74 | 0.082 | 1.85 | 1.12–1.98 | 0.099 |
Lipid-lowering agent, yes | 1.42 | 0.436 | 1.27 | 0.52–1.87 | 0.362 |
RAS inhibitor, yes | 3.24 | 0.213 | 2.38 | 0.89–3.21 | 0.545 |
Quartiles of serum total bilirubin are as follows: ≤ 0.55, 0.55–0.71, 0.71–0.88, and > 0.88.
eGFR, estimated glomerular filtration rate; HR, hazard ratio; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; HbA1c, glycated hemoglobin; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; RAS, renin-angiotensin system.