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. 2017 May 31;32(5):875–882. doi: 10.3904/kjim.2015.153

Table 3.

Univariate and multivariate analysis for the development of chronic kidney disease stage 3 or greater (eGFR < 60 mL/min/1.73 m2) in the normoalbuminuria subgroup

Variable Univariate analysis
Multivariate analysis
HR p value HR 95% CI p value
Male sex 1.48 0.341 2.49 0.76–8.83 0.159
Age, yr 1.05 0.037 1.09 1.002–1.19 0.046
BMI, ≥ 25 kg/m2 0.38 0.056 0.65 0.58–1.03 0.094
Duration of diabetes, yr 0.95 0.594 0.83 0.66–1.05 0.113
Hypertension, yes 1.42 0.164 2.24 0.72–1.23 0.243
SBP, mmHg 1.21 0.142 1.34 0.82–1.41 0.564
HbA1c, ≥ 7% 1.12 0.143 1.62 0.73–1.24 0.728
Hemoglobin 0.86 0.034 0.78 0.43–0.92 0.125
LDL-C, ≥ 100 mg/dL 1.92 0.309 1.67 0.69–1.84 0.384
HDL-C, ≤ 40 mg/dL (M), ≤ 50 mg/dL (F) 1.62 0.732 1.26 0.52–2.85 0.826
Triglycerides, ≥ 150 mg/dL 1.62 0.522 1.33 0.91–2.42 0.423
Total bilirubin
 Q1 3.77 0.094 7.36 1.24–35.82 0.019
 Q2 2.71 0.222 5.37 0.94–24.32 0.060
 Q3 0.85 0.872 0.95 0.35–1.04 0.959
 Q4 1.00 0.148 1.00 - 0.040
Diabetic retinopathy, yes 1.74 0.082 1.85 1.12–1.98 0.099
Lipid-lowering agent, yes 1.42 0.436 1.27 0.52–1.87 0.362
RAS inhibitor, yes 3.24 0.213 2.38 0.89–3.21 0.545

Quartiles of serum total bilirubin are as follows: ≤ 0.55, 0.55–0.71, 0.71–0.88, and > 0.88.

eGFR, estimated glomerular filtration rate; HR, hazard ratio; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; HbA1c, glycated hemoglobin; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; RAS, renin-angiotensin system.