Table 2.
Immunohistochemistry results of tissue biopsy samples and cytogenetic features of bone marrow aspirates
| Patient no. | Biopsy site | CD4 | CD56 | CD123 | TdT | CD3 | CD20 | MPO | Lysozyme | Ki-67, % | Other IHC and ISH | Bone marrow cytogenetics |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | Skin | + | + | + | + | - | - | - | - | 40 | CD8-, CD10-, CD79a-, CD30-, ALK-, Bcl6-, EBV ISH- | No abnormal cytogenetics |
| #2 | Skin | + | + | + | + | - | - | - | + (5%) | 10 | CD13- | No abnormal cytogenetics |
| #3 | Skin | + | + | + | + | - | - | - | - | 10 | - | 46,XY,+1,der(1;15)(q10;q10),del(12)(p11.2),-13,+16 [10]/46,XY [10] |
| #4 | Skin | + | + | + | - | - | - | - | - | 1 | CD13-, CD30-, CD79a-, CD138- | No abnormal cytogenetics |
| #5 | Skin | + | + | + | + | - | - | - | - | 30 | CD8-, CD30-, ALK-, EBV ISH- | 45,X,-Y [6]/46,XY [14] |
| #6 | Skin | + | + | + | + | - | - | - | NA | NA | CD8-, CD10-, CD30-, CD34-, EBV ISH- | No abnormal cytogenetics |
| #7 | Skin | + | + | + | - | - | - | - | - | 50 | CD30-, ALK-, EBV ISH- | 45,X,Y,t(1;3)(p36.1;q21),t(2;6)(q35;q23),der(3),t(1;3),del(5)(q15q31),add(8)(q24.1),del(13)(q12q22),-14, add(21)(p11.2),+mar [14]/ 46,XY [6] |
| #8 | Skin | + | + | + | - | - | - | - | - | 1 | CD30-, CD34-, CD68-, CD79a-, CD13-, ALK- | No abnormal cytogenetics |
| #9 | Soft tissue | + | + | + | - | - | - | - | - | NA | CD68-, CD79a-, c-Kit- | No abnormal cytogenetics |
| #10 | Lymph node | NA | + | + | - | - | - | - | NA | NA | - | No abnormal cytogenetics |
TdT, terminal deoxynucleotidyl transferase; MPO, myeloperoxidase; IHC, immunohistochemistry; ISH, in situ hybridization; NA, not applicable.