Table 1.
Hepatocellular carcinoma associated long non-coding RNAs in this review
| LncRNA | Chromosomal location | Dysregulation | Biological roles | Ref. |
| H19 | 11p15.5 | Up-regulated | Promotes HCC growth | Matouk et al[93] |
| Down-regulated | Inhibits migration and invasion of HCC cells | Lv et al[98] | ||
| HOTAIR | 12q13.13 | Up-regulated | Promotes HCC growth | Geng et al[107] |
| HOTTIP | 7p15.2 | Up-regulated | Promotes proliferation of HCC cells | Quagliata et al[115] |
| HULC | 6p24.3 | Up-regulated | Promotes HCC growth | Zhang et al[127] |
| MALAT1 | 11q 13.1 | Up-regulated | Promotes invasion | Lai et al[148] |
| MVIH | 10q22-q23 | Up-regulated | Promotes HCC growth, microvascular invasion, and intrahepatic metastasis | Shi et al[153] |
| MEG3 | 14q32.2 | Down-regulated | Inhibits cell growth | Zhu et al[166] |
| Lnc-FTX | Xq13.2 | Up-regulated | Promotes proliferation and cell cycle progression of HCC cells | Liu et al[175] |
| Down-regulated | Inhibits proliferation and cell cycle progression of HCC cells | Liu et al[176] |
HCC: Hepatocellular carcinoma; LncRNA: Long non-coding RNA; H19: H19, imprinted maternally expressed transcript; HOTAIR: HOX antisense intergenic RNA; HOTTIP: HOXA transcript at the distal tip; HULC: Highly up-regulated in liver cancer; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; MEG3: Maternally expressed gene 3; MVIH: Microvascular invasion in HCC; FTX: Five prime to Xist.