Skip to main content
. 2017 Aug 30;11:20. doi: 10.3389/fnint.2017.00020

Figure 5.

Figure 5

Brain regions associated with processing visual information display enriched col25a1 expression. (A) Schematic depicting major retino-recipient nuclei that receive input from retinal ganglion cells (in pink). Relay cells in the dorsal lateral geniculate nucleus (dLGN) transmit visual information to primary visual cortex (vCTX). SCN, suprachiasmatic nucleus; vLGN, ventral lateral geniculate nucleus; OPN, olivary pretectal nucleus; SC, superior colliculus. (B) Localization of col25a1 mRNA by ISH in retino-recipient nuclei of coronal sections of P25 mouse brain. SCN, dLGN, vLGN, and OPN are highlighted by blue circles. (C) Expression of col25a1 mRNA in vCTX (of coronal sections of P25 mouse brain) is dramatically lower than in retino-recipient regions. (D) col25a1 mRNA expression obtained by RNAseq in developing mouse dLGN and vLGN. ***Indicates p < 0.0001 comparing col25a1 mRNA level in vLGN of P12 to vLGN of all other ages by ANOVA. #Indicates p < 0.0001 comparing col25a1 mRNA level in dLGN of P25 mice to P3 and P8 dLGN by ANOVA. n = 4–5 samples per age and region. Scale bar = 200 μm.