Table 1. . Protozoan parasites that affect the host unfolded protein response.
Parasite | Infection model | Affected host UPR branch/component | Ref. |
---|---|---|---|
Plasmodium berghei | In vitro (Hepa 1–6 cells), In vivo (C57BL/6 mice; liver) | IRE1-XBP1, PERK, ATF6 | [61] |
|
In vivo (C57BL/6 mice; brain) |
IRE1-XBP1, PERK, ATF6 |
[62] |
Toxoplasma gondii | In vivo (BALB/c mice), In vitro (293T, HFFs cells) | ATF6 | [63] |
In vitro (murine neural stem cells) | CHOP | [64] | |
|
In vitro (C17.2 neural cells) |
CHOP |
[65] |
Cryptosporidium parvum |
In vitro (HCT-8 cells) |
PERK/NRF2 |
[66] |
Leishmania amazonensis |
In vitro (RAW 264.7 cells; murine primary macrophages) |
IRE1-XBP1 |
[67] |
Leishmania infantum | In vitro (U937 cells; murine primary macrophages) | XBP1, PERK-ATF4 | [68] |
UPR: Unfolded protein response.