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. 2017 May 12;3(3):FSO198. doi: 10.4155/fsoa-2017-0020

Table 1. . Protozoan parasites that affect the host unfolded protein response.

Parasite Infection model Affected host UPR branch/component Ref.
Plasmodium berghei In vitro (Hepa 1–6 cells), In vivo (C57BL/6 mice; liver) IRE1-XBP1, PERK, ATF6 [61]
 
In vivo (C57BL/6 mice; brain)
IRE1-XBP1, PERK, ATF6
[62]
Toxoplasma gondii In vivo (BALB/c mice), In vitro (293T, HFFs cells) ATF6 [63]
  In vitro (murine neural stem cells) CHOP [64]
 
In vitro (C17.2 neural cells)
CHOP
[65]
Cryptosporidium parvum
In vitro (HCT-8 cells)
PERK/NRF2
[66]
Leishmania amazonensis
In vitro (RAW 264.7 cells; murine primary macrophages)
IRE1-XBP1
[67]
Leishmania infantum In vitro (U937 cells; murine primary macrophages) XBP1, PERK-ATF4 [68]

UPR: Unfolded protein response.