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. 2017 Aug 23;6(8):e77. doi: 10.1038/emi.2017.67

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Copyright © 2017 The Author(s)

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Renal infection of Zika virus (ZIKV) in AG6 mice. (A) Components of the nephron. (B) Detection of ZIKV RNA in mouse kidneys. Left panel, in situ hybridization (ISH) using a ZIKV-specific probe. Blue and red arrows indicate renal glomerular and tubular cells, respectively. Hybridization signals of ZIKV RNA were developed by a chromogenic reaction and are observed as black particles. Right panel, hematoxylin and eosin (H&E) staining. Scale bar, 50 μm. (C) Immunofluorescence staining of caspase-3 in ZIKV-infected renal tissues of AG6 mice. Left panel, representative images. Scale bar, 200 μm. Right panel, statistical analyses of caspase-3-positive cells. **Significant difference between mock and infected cells (P<0.01; Student’s t-test).