Analysis of primary tumor location. A, Breakdown of primary melanoma site and number of BM detected (numerous, >1; solitary, 1). B, Breakdown of primary melanoma site and detection setting for BM (symptoms vs. routine screening). C, Distribution of primary melanoma sites by sex. Two-sided Fisher's Exact tests were used for analyses of primary site and number of BM, detection setting, and sex (see text). Patients with brain metastasis (BM) were grouped by site of primary melanoma and times (in months, m) to D, development of first recurrence; E, diagnosis of first BM; and F, death were plotted. G-I, Subset analyses of patients with primary head and neck (excluding scalp) and scalp tumors. Number of patients (n) in each group and median times to events are shown in parentheses. P values based on log rank tests.