Table 9. Dose estimates and deviations from physical dose for CNL test samples after applying image selection models.
| Image selection model | INTC03S01
3.1 * |
INTC03S08
2.3 |
INTC03S04
1.8 |
INTC03S05
2.8 |
INTC03S07
3.4 |
|---|---|---|---|---|---|
| All images | 4, +0.9, out
of bounds |
2.6, +0.3 | 2.45, +0.65 | 3.6, +0.8 | 4, +0.6, out
of bounds |
| Combined Z Score,
weight [5, 2, 4, 3, 4, 1] ^, top 250 |
3.9, +0.8 | 2.8, +0.5 | 2.1, +0.3 | 3.05, +0.25 | 3.55, +0.15 |
| Combined Z Score,
weight [4, 3, 4, 5, 2, 1], top 250 |
4, +0.9, out of bounds | 2.75, +0.45 | 1.7, -0.1 | 3.05, +0.25 | 3.9, +0.5 |
| Combined Z Score,
weight [1, 2, 1, 5, 1, 5], top 250 |
3.6, +0.5 | 2.4, +0.1 | 0.65, -1.15 | 2.35, -0.45 | 3.05, -0.35 |
| Chromosome group bin
method ^, top 250 |
4, +0.9, out of bounds | 2.8, +0.5 | 1.8, +0.0 | 2.55, -0.25 | 4, +0.6 |
| Filters I-VI | 3.75, +0.65 | 2.8, +0.5 | 1.95, +0.15 | 3.05, +0.25 | 3.4, +0.0 |
| Filters I-III &
chromosome group bin method, top 250 |
4, +0.9,
out of bounds |
2.75, +0.45 | 1.65, -0.15 | 2.25, -0.55 | 3.95, +0.55 |
| Manual image curation | 3.7, +0.6 | 2.85, +0.55 | 2.2, +0.4 | 2.8, +0.0 | 3.5, +0.1 |
*Sample identifier, physical dose (Gy). False positive filters were enabled. Out of bounds indicates that the estimated dose exceeded the maximum calibrated dose.
^ Figure 6 indicates the effect of these image selection models on DC frequency for INTC03S01, INTC03S08, INTC03S10 as a function of the number of images analyzed.