Table 2.
Cancer pathway genes significantly upregulated after Rep stress (but not after Acu)
| Gene ID/ Accession | Gene name | Fold change Con vs Rep |
Molecular function/biological process |
|---|---|---|---|
| Acly P16638 | ATP citrate lyase | 2.14 | Lyase enzyme/metabolism (bioenergetics) |
| Angpt1 O35460 | Angiopoietin 1 | 1.91 | Vascular growth factor/angiogenesis |
| Apaf1 Q9EPV5 | Apoptotic peptidase activating factor 1 | 1.42 | Endopeptidase/apoptosis |
| Atp5a1 P15999 | ATP synthase, H+ transpoting, mitochondrial F1 complex, alpha subunit | 1.84 | ATP synthesis/metabolism (bioenergetics) |
| Casp2 P55215 | Caspase 2 | 2.10 | Endopeptidase/apoptosis |
| Casp7 O88550 | Caspase 7 | 1.87 | Endopeptidase/apoptosis |
| Casp9 Q920G4 | Caspase 9, apoptosis-related cysteine peptidase | 1.96 | Endopeptidase/apoptosis |
| Ccnd3 P48961 | Cyclin D3 | 1.54 | Kinase/cell cycle regulation |
| Cdc20 Q62623 | Cell division cycle 20 homolog (S. cerevisiae) | 1.92 | Regulatory protein/cell cycle regulation |
| Cdh2 Q9Z1Y3 | Cadherin 2 | 3.07 | Cell adhesion |
| Cflar C0H5Y5 | CASP8 and FADD-like apoptosis regulator | 2.08 | Endopeptidase/apoptosis |
| Cpt2 P18886 | Carnitine palmitoyltransferase 2 | 2.06 | Lipid transferase/metabolism (fatty acid) |
| Dkc1 P40615 | Dyskeratosis congenita 1, dyskerin | 1.66 | rRNA processing/proliferation |
| E2f4 D4A9V4 | E2F transcription factor 4 | 2.10 | Transcription factor/proliferation |
| Ercc5 D3ZTV2 | Excision repair cross-complementing rodent repair deficiency, Complementation group 5 | 1.85 | Endonuclease/DNA excision repair |
| Flt1 P53767 | Fms-related tyrosine kinase 1 | 2.77 | Growth factor receptor/proliferation, migration |
| Foxc2 Q63246 | Forkhead box C2 | 1.91 | Transcription factor/proliferation, differentiation |
| G6pd P05370 | Glucose −6-phosphate dehydrogenase | 2.38 | Dehydrogenease/metabolism (carbohydrates) |
| Igfbp7 Q5RJM3 | Insulin-like growth factor binding protein 7 | 1.89 | Growth factor binding/response to hormones |
| Map2k1 Q01986 | Mitogen activated protein kinase kinase 1 | 1.83 | Mitogenic protein kinase/proliferation |
| Nol3 Q62881 | Nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.11 | Regulatory protein/apoptosis |
| Pgf Q63434 | Placental growth factor | 1.60 | Growth factor/proliferation, differentiation |
| Pp1r15a Q6IN02 Ppp1r15a |
Protein phosphatase 1, regulatory (inhibitor) subunit 15A | 1.91 | Phosphatase/apoptosis |
| Sod1 P07632 | Superoxide dismutase 1, soluble | 1.96 | Dismutase enzyme/oxidative stress |
| Wee1 Q63802 | Wee 1 homolog (S. pombe) | 1.29 | Kinase/cell cycle regulation |
Bold text denotes proto-oncogenes. Accession numbers and molecular function/biological process obtained from UniProtKB database