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. 2017 Sep 4;18:165. doi: 10.1186/s13059-017-1285-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Change in PCHi-C interactions correlate with change in gene expression. a Distribution of significant (FDR < 0.01) fold changes induced by activation of CD4⁺ T cells in (top) gene expression and (bottom) differential PCHi-C interactions for differentially expressed genes in by module. b Median significant expression and interaction fold changes by module are correlated (Spearman rank correlation)