Table 3.
Risk Factor Analysis for Reoperation for Glaucoma After 5 Years of Follow-up in the Tube Versus Trabeculectomy Study
| Risk Factor | Number (%) |
Cumulative Probability of Reoperation for Glaucoma (%)b |
P-value | |
|---|---|---|---|---|
|
| ||||
| Univariatec | Multivariated | |||
|
| ||||
| Stratuma | .45 | .54 | ||
| 1 | 94 (44) | 14.1 | ||
| 2 | 49 (23) | 30.3 | ||
| 3 | 35 (17) | 7.6 | ||
| 4 | 34 (16) | 17.6 | ||
|
| ||||
| Age (years) | .11 | .12 | ||
| < 60 years | 31 (15) | 16.4 | ||
| 60–69 | 59 (28) | 47.4 | ||
| 70–79 | 79 (37) | 12.0 | ||
| ≥ 80 | 43 (20) | 6.2 | ||
|
| ||||
| Gender | .40 | .43 | ||
| Male | 100 (47) | 16.5 | ||
| Female | 112 (53) | 20.7 | ||
|
| ||||
| Race | .11 | .12 | ||
| White | 95 (45) | 10.7 | ||
| Black | 82 (39) | 31.6 | ||
| Hispanic | 30 (14) | 3.8 | ||
| Other | 5 (2) | 50.0 | ||
|
| ||||
| Diabetes mellitus | .18 | .18 | ||
| Yes | 67 (32) | 20.5 | ||
| No | 145 (68) | 17.2 | ||
|
| ||||
| Hypertension | .36 | .22 | ||
| Yes | 124 (59) | 19.9 | ||
| No | 88 (42) | 17.0 | ||
|
| ||||
| Lens status | .34 | .35 | ||
| Phakic | 45 (21) | 14.5 | ||
| PCIOL | 160 (76) | 18.3 | ||
| ACIOL | 7 (3) | 31.4 | ||
|
| ||||
| Previous intraocular surgery | .27 | .13 | ||
| 1 | 163 (77) | 18.3 | ||
| 2 | 41 (19) | 19.9 | ||
| 3 or 4 | 8 (4) | 27.1 | ||
|
| ||||
| Time since last intraocular surgery (months) | .76 | .89 | ||
| < 6 months | 15 (7) | 14.4 | ||
| ≥ 6 months | 190 (93) | 18.6 | ||
|
| ||||
| Glaucoma type | .31 | .14 | ||
| Primary | 190 (90) | 18.3 | ||
| Secondary | 22 (10) | 18.2 | ||
|
| ||||
| Preoperative number of glaucoma medications | .86 | .58 | ||
| 0–1 | 21 (10) | 10.0 | ||
| 2–3 | 108 (51) | 21.1 | ||
| 4–6 | 83 (39) | 15.2 | ||
|
| ||||
| Preoperative IOP (mm Hg) | .61 | .67 | ||
| < 23 | 77 (36) | 21.7 | ||
| 23–26 | 66 (31) | 18.7 | ||
| > 26 | 69 (33) | 13.9 | ||
|
| ||||
| Preoperative Snellen VA | .27 | .58 | ||
| ≥ 20/30 | 106 (50) | 12.1 | ||
| 20/40–20/150 | 74 (35) | 20.0 | ||
| ≤ 20/200 | 32 (15) | 38.9 | ||
|
| ||||
| Clinical Centers | .38 | .40 | ||
| Enrolled ≥ 50% patients | 133 (63) | 19.0 | ||
| Enrolled < 50% patients | 79 (37) | 15.9 | ||
|
| ||||
| Treatment | .025 | - | ||
| Tube | 107 (50) | 9.1 | ||
| Trabeculectomy | 105 (50) | 29.3 | ||
ACIOL = anterior chamber intraocular lens; IOP = intraocular pressure; PCIOL = posterior chamber intraocular lens; VA = visual acuity
a
Stratum 1 = previous cataract extraction; stratum 2 = previous trabeculectomy or combined procedure without an antifibrotic agent; stratum 3 = previous trabeculectomy with 5-fluorouracil or combined procedure with 5-fluorouracil or mitomycin C; stratum 4 = previous trabeculectomy with mitomycin
b
Kaplan-Meier survival analysis
c
Log-rank test
d
Cox proportional hazard regression analysis, p value adjusted for treatment.