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. 2017 Sep 4;214(9):2523–2533. doi: 10.1084/jem.20161427

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Figure 2. — High pSTAT1 drives increased PD-L1 expression in STAT3 LOF and STAT1 GOF cells. (A) PD-L1 expression on naive (CD45RO⁻) T cells from HCs and patients after 24 h of stimulation with IL-27. Naive (CD45RO⁻) CD4⁺ T cells were transfected with STAT1 RNAi or scramble RNAi (B and C), SOCS3-GFP or GFP-control (D), or SOCS3 RNAi or scramble RNAi (E). (B) STAT1 expression after transfection with STAT1 RNAi. (C–E) PD-L1 expression 41 h after IL-27 stimulation. One-way ANOVA (A) and paired Student’s t tests (C–E) were performed. *, P < 0.05; **, P < 0.01. Data are representative of three independent experiments unless otherwise indicated on the graph; graphs show means ± SEM. MFI, mean fluorescence intensity.