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. 2017 Sep 4;214(9):2523–2533. doi: 10.1084/jem.20161427

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Figure 3. — Th17 cytokine production is impaired in STAT3 LOF and STAT1 GOF T cells, and IL-17A can be partially restored by blocking PD-L1. Naive CD4⁺ T cells from HCs and patients were cultured for 6 d under Th0 or Th17 conditions in the presence of PD-L1 blocking antibody (anti-PD-L1) or control IgG. Expression of IL-17A and IL-17F (A–D), PD-1 (E), and PD-L1 (F) were analyzed. (G) IL17A, IL17F, and RORC mRNA levels in cells are shown. One-way ANOVA between genotypes (C–G) and paired Student’s t tests (B) were performed. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Data are representative of three independent experiments. Graphs show means ± SEM.