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. 2017 Sep 4;214(9):2649–2670. doi: 10.1084/jem.20161900

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© 2017 Yang et al.

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Figure 3. — HK deficiency ameliorates LPS-induced multiple organ injury. (A and B) Kng1^−/− mice and their littermate control mice were challenged with PBS (control) or LPS (5 mg/kg) for 48 h (n = 6), followed by organ harvest. Lung tissue was processed for hematoxylin and eosin (H&E) staining (A) and scanning electron microscopy (B), and the representative images are shown. Bars, 100 µm (A) and 500 µm (B). (C) Total protein concentration and white blood cells in BALF and MPO activity in lung homogenates were measured. White column, control WT mice; gray column, Kng1^−/− mice. Data were analyzed using an unpaired Student's t test and are representative of two independent experiments. *, P < 0.05. Data are expressed as mean ± SEM. (D and E) Liver and kidney were processed for H&E staining, and representative images for liver (D) and kidney (E) are shown. Bars, 100 µm.