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. 2017 Sep 4;214(9):2795–2810. doi: 10.1084/jem.20161955

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Figure 6. — GC responses are elicited by CD40 KO DCs and B7 KO B cells. (A) B cells were purified from B7 DKO mice and adoptively transferred to CD40 KO mice. Host mice were immunized with NP-OVA/Alum 1 d after transfer. 8 d later, splenocytes were analyzed for antigen-specific GC B population. (B) Frequency of GC B cells, NP-binding GC B cells in each B cell compartment, and frequency of IgG1⁺ cells among NP-binding GC B cells were analyzed. Data presented are the combined result of three independent experiments (mean ± SEM). The total numbers of mice in the three combined experiments are WT, n = 7; CD40 KO, n = 6; B7 DKO B cells into CD40 KO mice, n = 8; and CD40 KO B cells into B7 DKO mice, n = 3. Statistical significance was determined by Student’s t test.