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. 2017 Sep 4;214(9):2491–2506. doi: 10.1084/jem.20170910

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© 2017 Cildir et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Evolutionary adaptations of mast cell functions. Mast cell–derived mediators are critically involved in the detoxification of arthropod and reptile venoms. For example, whereas CPA3 is involved in the inhibition of Sarafotoxin 6B, MCPT4 is critical for the inhibition of Helodermin. Mast cells also contribute to the T_h2-type immune response, which is critical for the prevention of helminth infections.