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. 2017 Jun 13;8(31):50403–50414. doi: 10.18632/oncotarget.18468

Figure 4.

Figure 4

Immunohistochemical and immunofluorescent double-staining of GBM tissue samples revealed strong P-AXL expression in CD31 positive endothelial cells (A., B., D.; arrowheads), no colocalization with aSMA (B., C., D.), and partial colabeling with PDGFR-ß positive pericytes (E.; arrowheads) in microvascular proliferation. Glioma cells adjacent to microvascular proliferation (dashed lines) showed strong immunopositivity for PDGFR-ß (E.; arrows). P-AXL was further expressed by neoplastic glioma cells as noted by colabeling with GFAP (F.-H.; arrowheads), MAP2 (I.-K.; arrowheads), Nestin (L.-N.; arrowheads), and ZEB1 O.-Q.; arrowheads). (Scale bar: 20 μm A., 50 μm B.-Q.).