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. 2017 Apr 20;8(31):50415–50429. doi: 10.18632/oncotarget.17304

Table 1. Basic information for included studies of the association between IFNG +874 T/A (rs2430561) polymorphism site and tuberculosis susceptibility.

First author Year Origin Source of Control Ethnicity Type Sample size Case Control Case Control Control Methods NOS
Ref No TT TA AA MAF HWE TT TA AA MAF HWE
Amim*[34] 2008 Brazil HB Mixed TB <100 93 266 15 25 53 0.296 0.0006 67 88 111 0.417 0.001 PCR-ARMS 6
Anand[21] 2010 India HB Asian PTB <100 62 66 7 27 28 0.331 0.898 8 25 33 0.311 0.35 PCR-ASP 6
Ansari*[53] 2009 Pakistan HB Asian PTB >100 111 188 27 47 37 0.455 0.123 25 87 76 0.364 0.98 PCR-ARMS 7
Ansari*[53] 2009 Pakistan HB Asian EPTB <100 77 188 12 36 29 0.389 0.881 25 87 76 0.364 0.98 PCR-ARMS 7
Anuradha*[27] 2008 India PB Asian Children TB <100 25 90 5 13 7 0.46 0.815 29 42 19 0.555 0.6 PCR 6
Asgharzadeh[64] 2016 Iran PB Asian TB >100 124 200 10 42 72 0.25 0.281 28 81 91 0.342 0.15 PCR-ARMS 8
Bhanothu[47] 2015 India HB Asian EPTB >100 175 100 45 87 43 0.506 0.941 29 62 9 0.6 0.003 ARMS-MG/
MP-PCR		 6
Cooke*[36] 2006 UK PB African PTB >100 667 597 20 159 488 0.149 0.115 13 166 415 0.162 0.45 PCR-ARMS 6
Ding*[26] 2008 China PB Asian TB >100 301 310 19 89 193 0.211 0.052 32 114 164 0.287 0.07 sequencing 8
Etokebe*[40] 2005 Croatia HB Caucasian TB >100 242 519 53 122 67 0.471 0.637 103 282 134 0.47 0.04 PCR-ASP 6
Fitness*[48] 2004 Malawi PB African TB >100 451 703 12 134 305 0.175 0.549 17 219 467 0.179 0.14 PCR-ARMS 8
Gutlapalli[32] 2016 India HB Asian TB >100 247 129 73 123 51 0.544 0.951 60 58 11 0.689 0.56 PCR-ARMS 6
Hashemi[20] 2011 Iran PB Asian PTB >100 142 166 18 84 40 0.422 0.011 33 111 22 0.533 0.001 PCR-ARMS 7
Hu[45] 2015 China PB Asian TB >100 360 480 36 124 200 0.272 0.013 67 201 212 0.349 0.08 PCR-ARMS 7
Hwang*[50] 2007 Korea PB Asian PTB <100 80 80 1 13 66 0.094 0.696 0 21 59 0.131 0.17 PCR-ARMS 7
Leandro[43] 2013 Brazil PB Mixed TB >100 172 179 22 78 72 0.354 0.902 26 91 62 0.399 0.42 PCR-ARMS 8
Lee[44] 2015 Taiwan PB Asian TB >100 200 202 131 56 13 0.795 0.046 144 54 4 0.846 0.68 TaqMan 8
Lio[9] 2002 Italy PB Caucasian PTB <100 45 97 4 30 11 0.422 0.013 25 47 25 0.5 0.06 PCR-ARMS 8
Lopez-
Maderuelo*[39]		 2003 Spain PB Caucasian PTB >100 113 100 11 40 62 0.274 0.238 19 50 31 0.44 0.88 PCR 6
Ma*[49] 2007 China PB Asian PTB <100 60 60 2 10 48 0.117 0.138 8 20 32 0.3 0.11 PCR-SSP 6
Mabunda[29] 2015 Brazil HB Mixed PTB >100 101 360 3 32 66 0.188 0.708 21 136 203 0.247 0.77 TaqMan 7
Moran*[30] 2007 USA PB African TB >100 240 174 9 87 144 0.219 0.348 11 65 98 0.25 0.96 sequencing 7
Moran*[30] 2007 USA PB Caucasian TB <100 161 64 24 92 45 0.435 0.039 16 31 17 0.492 0.8 sequencing 7
Moran*[30] 2007 USA PB Caucasian TB <100 319 98 24 96 199 0.226 0.013 10 26 62 0.235 0.01 sequencing 7
Mosaad[42] 2010 Egypt HB Caucasian TB >100 110 118 32 60 18 0.563 0.253 52 60 6 0.695 0.03 PCR-ARMS 6
Onay*[22] 2010 Turkey HB Caucasian Children TB <100 40 67 9 22 9 0.5 0.527 16 35 16 0.5 0.71 PCR-ARMS 6
Oral*[35] 2006 Turkey PB Caucasian TB <100 81 50 21 29 31 0.438 0.014 8 21 21 0.37 0.48 PCR-SSP 8
Rossouw*[38] 2003 UK PB African TB >100 313 235 25 102 186 0.243 0.078 26 98 111 0.319 0.53 PCR 6
Sallakci*[33] 2007 Turkey HB Caucasian TB >100 361 115 50 182 129 0.391 0.262 26 58 31 0.478 0.91 sequencing 6
Selma*[25] 2011 Tunisia PB African TB >100 223 150 38 85 100 0.361 0.009 22 86 42 0.433 0.04 PCR-RFLP 7
Selvaraj*[52] 2008 India HB Asian PTB >100 160 178 20 72 68 0.35 0.889 23 76 79 0.342 0.48 PCR-RFLP 7
Shen[28] 2013 China PB Asian Children TB >100 189 164 136 53 0 0.859 0.024 133 29 2 0.899 0.77 sequencing 6
Tso*[37] 2005 Hong Kong HB Asian TB >100 385 451 17 101 267 0.175 0.068 55 190 206 0.332 0.28 sequencing 6
Vallinoto*[23] 2010 Brazil PB Mixed TB >100 162 156 11 58 93 0.247 0.635 24 86 46 0.429 0.12 PCR-ASO 7
Vidyarani*[31] 2006 India HB Asian PTB >100 129 127 14 54 61 0.318 0.694 20 52 55 0.362 0.2 PCR-ARMS 6
Wang*[54] 2011 China HB Asian PTB >100 273 297 3 78 192 0.154 0.107 3 84 210 0.151 0.08 PCR-RFLP 6
Wang*[24] 2010 China PB Asian PTB >100 521 526 14 80 427 0.104 <0.001 10 91 425 0.105 0.06 PCR-RFLP 6
Wit*[51] 2011 South Africa PB Mixed TB >100 500 315 40 194 266 0.274 0.579 33 124 158 0.301 0.24 PCR-RFLP 6
Wu*[41] 2008 China PB Asian PTB <100 61 122 1 10 50 0.098 0.554 2 24 96 0.114 0.72 PCR-RFLP 8
Yang*[57] 2010 China HB Asian PTB >100 189 191 6 41 142 0.14 0.168 3 49 139 0.143 0.57 PCR-SSP 6
Zhong[55] 2014 China HB Asian PTB >100 142 166 4 26 112 0.119 0.117 7 49 110 0.189 0.61 TaqMan 6
Zhuang[56] 2009 China HB Asian PTB >100 167 167 12 53 102 0.231 0.172 37 70 60 0.431 0.06 PCR-SSP 5

HWE: Hardy–Weinberg equilibrium; HB: hospital-based; PB: population-based; TB: tuberculosis; PTB: pulmonary TB, EPTB: extra-pulmonary TB; PCR-FLIP: polymerase chain reaction and restrictive fragment length polymorphism; PCR-ARMS: polymerase chain reaction-amplification refractory mutation specific; PCR-ASP: allele specific primers by polymerase chain reaction, PCR-SSP: polymerase chain reaction-sequence specific primer; PCR-ASO: polymerase chain reaction-allele-specific oligonucleotide; ARMS-MG/MP-PCR: Amplification refractory mutation system-multi gene/multi primer polymerase chain reaction; NOS: Newcastle-Ottawa Scale; *: studies reported in previous meta-analysis; bold: these nine studies including both PTB and EPTB.