Table 2. Total and stratified subgroup analysis for IFNG +874 T/A(rs2430561) polymorphism site and tuberculosis susceptibility.
| Variables | N | Case/ | Allelic effect | Additive model (TA vs. AA)/(TT vs. AA) | Dominant model | Recessive model | Overdominant model | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | OR(95%CI) Ph P | OR(95%CI) Ph P | OR(95%CI) Ph P | OR(95%CI) Ph P | OR(95%CI) Ph P | ||||||
| Total | 42 | 8574/9011 | 0.75 (0.68-0.82) 1×10-6 1×10-6 | 0.71 (0.63-0.80) 1×10-6 1×10-6/0.60 (0.49-0.73) 1×10-6 1×10-6 | 0.68 (0.60-0.77) 1×10-6 1×10-6 | 0.72 (0.62-0.83) 0.002 1×10-6 | 0.83 (0.76-0.92) 1×10-6 1×10-6 | ||||
| HWE | 35 | 7270/7594 | 0.75 (0.67-0.84) 1×10-6 1×10-6 | 0.74 (0.65-0.83) 1×10-6 1×10-6/0.62 (0.49-0.78) 1×10-6 1×10-6 | 0.71 (0.62-0.81) 1×10-6 1×10-6 | 0.70 (0.59-0.83) 0.004 1×10-6 | 0.85 (0.76-0.94) 0.001 0.002 | ||||
| Ethnicity | |||||||||||
| Asian | 23 | 4180/4648 | 0.73 (0.63-0.84) 1×10-6 1×10-6 | 0.68 (0.57-0.81) 1×10-6 1×10-6/0.58 (0.42-0.81) 1×10-6 0.001 | 0.65 (0.54-0.79) 1×10-61×10-6 | 0.70 (0.57-0.87) 0.004 0.001 | 0.83 (0.72-0.95) 0.005 0.006 | ||||
| Caucasian | 9 | 142/1228 | 0.79 (0.65-0.97) 0.013 0.025 | 0.83 (0.63-1.09) 0.095 0.181/0.60 (0.39-0.92) 0.014 0.019 | 0.77 (0.58-1.03) 0.036 0.078 | 0.70 (0.49-0.96) 0.003 0.028 | 0.99 (0.84-1.17) 0.135 0.926 | ||||
| African | 5 | 1894/1859 | 0.84 (0.75-0.95) 0.276 0.004 | 0.74 (0.57-0.94) 0.026 0.016/0.79 (0.58-1.09) 0.276 0.152 | 0.75 (0.60-0.94) 0.048 0.013 | 0.97 (0.72-1.30) 0.392 0.833 | 0.76 (0.61-0.95) 0.047 0.017 | ||||
| Mixed | 5 | 1028/1276 | 0.67 (0.52-0.84) 0.009 0.003 | 0.64 (0.45-0.92) 0.012 0.015/0.53 (0.42-0.72) 0.009 1×10-6 | 0.61 (0.42-0.87) 0.004 0.007 | 0.64 (0.48-0.85) 0.545 0.002 | 0.75 (0.57-0.97) 0.094 0.030 | ||||
| Source of Control | |||||||||||
| HB | 18 | 3064/3693 | 0.76 (0.64-0.91) 1×10-6 0.003 | 0.72 (0.59-0.87) 1×10-6 0.001/0.59 (0.41-0.86) 1×10-6 0.006 | 0.69 (0.54-0.86) 1×10-6 0.001 | 0.72 (0.55-0.94) 1×10-6 0.016 | 0.85 (0.73-0.98) 0.030 0.023 | ||||
| PB | 24 | 5510/5318 | 0.74 (0.68-0.82) 0.003 1×10-6 | 0.70 (0.61-0.81) 0.001 1×10-6/0.60 (0.49-0.75) 0.030 1×10-6 | 0.68 (0.59-0.79) 1×10-6 1×10-6 | 0.71 (0.63-0.82) 0.246 1×10-6 | 0.82 (0.72-0.94) 0.001 0.004 | ||||
| TB type | |||||||||||
| PTB | 25 | 4244/5107 | 0.73 (0.64-0.83) 1×10-6 1×10-6 | 0.68 (0.58-0.80) 0.001 1×10-6/0.60 (0.44-0.81) 1×10-6 0.001 | 0.66 (0.55-0.78) 1×10-6 1×10-6 | 0.71 (0.57-0.90) 0.006 0.004 | 0.80 (0.70-0.91) 0.008 0.001 | ||||
| EPTB | 10 | 984/1910 | 0.66 (0.55-0.79) 0.040 1×10-6 | 0.55 (0.39-0.77) 0.027 1×10-6/0.45 (0.27-0.75) 0.007 0.002 | 0.51 (0.36-0.73) 0.008 1×10-6 | 0.66 (0.49-0.89) 0.075 0.006 | 0.88 (0.66-1.17) 0.007 0.347 | ||||
| Sample size | |||||||||||
| <100 | 12 | 1104/1248 | 0.82 (0.67-0.99) 0.043 0.047 | 0.89 (0.72-1.09) 0.323 0.262/0.70 (0.53-0.94) 0.283 0.018 | 0.83 (0.69-1.01) 0.161 0.056 | 0.71 (0.54-0.92) 0.253 0.011 | 0.82 (0.67-0.99) 0.043 0.047 | ||||
| >100 | 30 | 7470/7763 | 0.73 (0.66-0.81) 1×10-6 1×10-6 | 0.67 (0.59-0.76) 0.000 0.000/0.56 (0.45-0.72) 0.000 0.000 | 0.64 (0.56-0.74) 1×10-6 1×10-6 | 0.71 (0.61-0.84) 0.001 1×10-6 | 0.81 (0.73-0.89) 0.001 1×10-6 | ||||
| Genotype methods | |||||||||||
| PCR-SSP | 4 | 497/468 | 0.64 (0.33-1.22) 1×10-6 0.177 | 0.60 (0.45-0.80) 0.109 0.001/0.58 (0.14-2.30) 1×10-6 0.437 | 0.57 (0.31-1.08) 0.002 0.088 | 0.69 (0.21-2.33) 0.002 0.558 | 0.68 (0.51-0.90) 0.555 0.007 | ||||
| PCR | 3 | 451/425 | 0.62 (0.50-0.77) 0.346 1×10-6 | 0.57 (0.42-0.77) 0.356 1×10-6/0.46 (0.29-0.72) 0.439 0.001 | 0.54 (0.41-0.72) 0.291 1×10-6 | 0.59 (0.38-0.90) 0.689 0.015 | 0.68 (0.51-0.90) 0.390 0.007 | ||||
| sequencing | 7 | 1956/1376 | 0.69 (0.55-0.86) 0.003 0.001 | 0.78 (0.55-1.11) 0.001 0.173/0.45 (0.34-0.59) 0.153 1×10-6 | 0.71 (0.50-1.00) 0.001 0.050 | 0.52 (0.41-0.66) 0.729 1×10-6 | 0.97 (0.69-1.37) 1×10-6 0.858 | ||||
| PCR-ARMS | 15 | 2845/3545 | 0.78 (0.68-0.90) 0.001 0.001 | 0.77 (0.69-0.86) 0.105 1×10-6/0.65 (0.46-0.92) 1×10-6 0.014 | 0.73 (0.61-0.87) 0.005 0.001 | 0.76 (0.59-0.98) 0.012 0.034 | 0.87 (0.79-0.97) 0.350 0.014 | ||||
| PCR-RFLP | 6 | 1738/1588 | 0.91 (0.80-1.03) 0.640 0.131 | 0.84 (0.65-1.08) 0.042 0.177/0.87 (0.64-1.18) 0.793 0.360 | 0.87 (0.75-1.01) 0.114 0.072 | 0.98 (0.73-1.31) 0.771 0.902 | 0.85 (0.67-1.09) 0.045 0.204 | ||||
| TaqMan | 3 | 443/728 | 0.67 (0.53-0.84) 0.771 0.001 | 0.59 (0.42-0.83) 0.377 0.002/0.39 (0.19-0.79) 0.714 0.009 | 0.57 (0.41-0.79) 0.357 0.001 | 0.72 (0.49-1.05) 0.795 0.084 | 0.79 (0.60-1.04) 0.149 0.095 | ||||
| PCR-ASP | 2 | 284/585 | 1.02 (0.83-1.24) 0.761 0.871 | 0.93 (0.67-1.29) 0.359 0.675/1.03 (0.68-1.55) 0.997 0.891 | 0.96 (0.71-1.31) 0.464 0.809 | 1.11 (0.78-1.58) 0.725 0.570 | 0.91 (0.69-1.20) 0.318 0.505 | ||||
Ph: value of Q-test for heterogeneity test; P: Z-test for the statistical significance of the OR. HWE: Except for seven studies[20,25,30,34,40,42,47], the distribution of genotypes in the controls in remaining 35 studies was in agreement with HWE, and it reports the meta-analysis results of studies showing no deviation from the HWE.