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. 2017 Sep 4;216(9):2603–2605. doi: 10.1083/jcb.201706113

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© 2017 Bobola

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — MEIS recruits PARP1 to activate Dcx transcription. In progenitor cells, Dcx is off. PBX (blue square) binds the Dcx promoter on closely spaced nucleosomes. After differentiation, MEIS (red circle) binds PBX and recruits PARP1 (green oval). Poly-ADP-ribosylation of linker histone H1 (orange rectangle) by PARP1 leads to H1 eviction and nucleosome decompaction, allowing Dcx transcription to begin.