Figure 5. Reduced intestinal tumor burden in Apc^Min/+LMP7^-/- mice.

16-week old Apc^Min/+ (black dots) or Apc^Min/+LMP7^-/- (blue squares) mice were analyzed for colonic tumor formation and small intestinal polyps (n = 5). A. The whole intestine was removed and opened longitudinally for macroscopic assessment of tumor and polyp formation. Number of small intestinal polyps of Apc^Min/+ or Apc^Min/+LMP7^-/- mice are shown; data are means ± SEM. B. Graph shows colonic tumor number, as defined by lesions ≥ 2 mm. Data are means ± SEM. C. Spleen weight of Apc^Min/+ or Apc^Min/+LMP7^-/- mice were assessed. According pictures of individual spleens are shown on the right. The graph represents data as means ± SEM. D. Average colon length of Apc^Min/+ (black column) or Apc^Min/+LMP7^-/- (blue column) mice at the age of 16 weeks. *p < 0.05, **p < 0.005.