Figure 2. Estimated cumulative risk of epithelial ovarian cancer in women with a germline truncating mutation in FANCM: Black line – population risk based on UK incidence data for 2009.

Blue line – estimated risk to FANCM carriers (dashed lines 80% confidence limits): A. average risks; B. risks to FANCM carriers at the 80^th centile of a polygenic risk distribution based on 18 known common risk alleles; C. risks to FANCM carriers at the 80^th centile of a risk distribution based on 18 known common risk alleles together with known lifestyle risk factors.