Table 2. Treatment characteristics.
Primary resection | Additional resections* | Radicality of resection | Interval between primary resection and HIPEC (weeks) | Interval between primary resection and adjuvant chemotherapy (weeks) | Adjuvant chemotherapy ** | |
---|---|---|---|---|---|---|
1 | Right hemicolectomy | Partial small bowel, abdominal wall | R1 | 6 | 10 | 4 x CAPOX4x capecitabin monotherapy |
2 | Proctocolectomy | Omental metastasis | R0 | 4 | 10 | 12 x FOLFOX |
3 | Subtotal colectomy | Omentum | R0 | 3 | 7 | 5 x CAPOX, 3x capecitabin monotherapy |
4 | Right hemicoloectomy | Omental metastasis, psoas muscle | R1 | 7 | 10 | 12 x FOLFOX |
5 | Low anterior resection | Hysterectomy, bilateral sapingectomy, ileocecal resection, omentectomy | R0 | 3 | 10 | 8x CAPOX |
6 | Subtotal colectomy | No | R0 | 6 | 8 | 8 x CAPOX |
7 | Low anterior resection | Partial small bowel, abdominal wall | R0 | 6 | 8 | 8x CAPOX |
8 | Right hemicolectomy | Omental metastasis | R0 | 9 | NA | Refused adjuvant systemic treatment |
9 | Right hemicolectomy | No | R0 | 6 | 12 | 6x FOLFOX |
10 | Low anterior resection | Ovarian metastasis | R1 | 4 | 8 | 8x CAPOX |
Median (range): 6(3-9) | Median (range): 10(7-12) |
CAPOX: combined schedule of capecitabin and oxaliplatin (standard 8 cycles); HIPEC = hyperthermic intraperitoneal chemotherapy; FOLFOX: combined schedule of 5-fluoruracil and oxaliplatin (standard 12 cycles); NA: not applicable; R0: microscopic complete tumour resection with all margins > 1mm; R1: microscopic margin involvement or margin ≤1mm.
*Additional resections, either of adjacent organs/structures because of suspected tumour ingrowth, or additional resections of metastases. ** Number of cycles and chemotherapeutic scheme.