Table 1. PEITC sensitive DUBs.

DUB	Cellular Role/Process	Substrate(s)	PEITC
USP1	DNA repair [37],Cell cycle [37, 94]Cisplatin resistance [39]Angiogenesis	PCNA [46] 1FANCD2 [95]ID1 [40]ID2 [40]ID3 [40]	↓ (this work)??↓ [24]↓ [24]
USP3	Chromatin remodeling [54]DNA repair [54]Interferon signaling/antiviral immunity [96]	H2A [97]H2B [54];RIG-1 [96]	↓ (this work)↓ (this work)?
USP10	DNA repair [98]Chromatin remodeling [98]Autophagy/endocytic recycling [99]	p53 [100, 101]BECN1 [102]SNX3 [103]CFTR [104]	↓ Mutant p53 [72]???
USP11	DNA repair [98, 105]Chromatin remodeling [105]Protein stabilityTranscription [106]Inflammatory Response [107]	cIAP2 [108]I-κBα [107]PCR1 [106]γH2AX [105]	↓ [109]???
USP16	DNA repair [52, 110]Chromatin remodeling [52, 110]Cell Cycle	H2A [111]	↓ (this work)
USP22	Chromatin remodeling [79]Cell proliferation [77, 79, 112]Protein stabilityGene expression [78, 113]Telomere maintenance [114]	H2A [115]H2B [116]TRF1 [114]COX-2 [80]FBP1 [81]	↓ (this work)↓ (this work)?↓ [84]↑ p21 [82, 83, 117]2
USP40	?	?	?
USP48	Inflammation/immune response [73]	NF-κB/RelA [73]	↓ NF-κB gene expression [74, 75]
UCH37	Chromatin remodeling [118]Cell cycle [119]Protein homeostasis [27]	Polyubiquitin [27]	↑ K48 and K63-linked polyUb [23]
VCPIP1	Golgi Disassembly [86]	?	?

1. Abbreviations: RIG-I, retinoic acid-inducible gene 1; PCNA, Proliferating cell nuclear antigen; FANCD2, Fanconi Anemia, Complementation Group D2; H2A, histone 2A; H2B, histone H2B; PCR1, polycomb repressive complex 1; FBP1, far upstream element (FUSE)-binding protein 1; COX-2, cyclooxygenase-2; TRF1, Telomeric repeat-binding factor 1; I-κBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; cIAP2, cellular inhibitor of apoptosis 2; BECN1, Beclin-1; SNX3, Sorting Nexin 3; CFTR, Cystic fibrosis transmembrane conductance regulator.

2. p21 is suppressed by FBP1 [81].