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. 2017 May 8;8(31):51447–51461. doi: 10.18632/oncotarget.17691

Figure 1. EX-527 administration promoted AS and enhanced macrophage infiltration in ApoE-/- mice.

Figure 1

In both administration schedules, ApoE-/- mice were treated with EX-527 at 10 mg/kg by i.p. for 4 wks (5 days per wk). The development of atherosclerotic plaques was monitored in the collared carotid artery using H&E (A) and ORO staining methods (B). The effect of EX-527 on macrophage accumulation in carotid atherosclerotic plaques was detected by Mac-2 immunostaining method (C). Scale bar: 25 μm. Arrows are indicative of representative Mac-2 immunostaining positively regions.