Table 1. Cells viability in response to different treatment in HCT116, HCT-8/5-FU or NCM460.
Rate of cell survival (%) | ||||||||
---|---|---|---|---|---|---|---|---|
HCT116 | Control | 5-FU | DTN | DHA | 5-FU+DTN | 5-FU+DHA | DTN+DHA | 5-FU+DTN+DHA |
24h | 100.03±8.08 | 98.61±12.04 | 98.49±8.79 | 104.80±10.12 | 94.65±7.14 | 97.62±9.24 | 96.51±9.22 | 89.51±10.28 |
48h | 101.21±7.14 | 85.85±10.96 | 84.62±8.23* | 90.43±8.08 | 75.71±6.16* | 77.50±8.05* | 79.14±10.56* | 65.28±7.55* |
72h | 99.23±6.18 | 77.10±7.69* | 73.24±10.02* | 85.47±9.08 | 67.35±9.90* | 69.14±7.11* | 73.92±6.17* | 57.80±7.13* |
HCT-8/5-FU | ||||||||
24h | 103.1±10.33 | 105.84±15.12 | 99.50±11.82 | 106.57±12.05 | 96.90±15.01 | 98.55±14.09 | 97.59±10.74 | 91.66±8.09 |
48h | 98.92±7.42 | 95.81±9.17 | 90.02±7.05 | 91.16±11.21 | 79.53±9.24* | 80.70±9.12* | 87.31±9.05 | 70.36±8.27* |
72h | 100.09±9.17 | 89.65±7.21 | 84.60±6.31 | 86.80±8.84 | 74.24±8.15* | 76.54±8.56* | 83.42±10.07* | 62.73±9.78* |
NCM460 | ||||||||
24h | 100.78±15.41 | 105.40±8.87 | 102.20±12.02 | 105.7±13.01 | 98.22±18.06 | 98.93±16.23 | 98.57±12.04 | 100.34±12.23 |
48h | 99.75±11.23 | 88.68±10.01 | 93.24±10.44 | 98.75±8.43 | 92.31±11.23 | 90.40±8.54 | 89.21±10.15 | 90.52±10.14 |
72h | 101.43±13.32 | 81.56±7.55* | 90.60±7.51 | 95.22±9.86 | 82.78±6.34 | 82.65±11.07 | 85.75±7.91 | 83.28±8.77 |
Notes: Data was showed as n = 5. * p<0.05 showed a significant difference compared to control group