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. 2017 May 16;8(31):51507–51521. doi: 10.18632/oncotarget.17882

Figure 7. BPA-stimulated HTR-8/SVneo cell migration, MMP-9 and integrin-β1 upregulation, as well as MAPK and PI3K signaling pathways activation.

Figure 7

(A) Western blot analyses of integrin-β1, MMP-9, and TIMP-3 protein levels and phosphorylation levels of ERK and Akt (p-Akt T308 and p-Akt S473) in HTR-8/SVneo cells exposed to BPA for 48 h with or without addition of U0126 (10 μM) and LY294002 (5 μM) for 24 h. *P < 0.05, **P < 0.01, ***P < 0.001. *P < 0.05 compared with vehicle control group; #P < 0.05 compared with the BPA treatment group. (B) Transwell assay detection of the migration of HTR-8/SVneo cells treated with BPA (10−6 M) and/or U0126 or LY294002. The Transwell assay was performed for six times. ***P < 0.001. Scale bar, 100 μm.