Skip to main content
. 2017 May 25;8(31):51591–51607. doi: 10.18632/oncotarget.18196

Figure 3. GT198+ pericytes give rise to tumor cells in human oral cancer.

Figure 3

Immunohistochemical staining of GT198 in 40 cases of human oral cancer. (A-D) In tumor adjacent tissues, GT198+ pericytes are thickened (B), detached from vessels (C), and overgrown into GT198+ tumor nodules (D). (E-F) GT198 positive nodules in primary cancer. (G-H) Positive nodules in lymph nodes. Boxed areas are enlarged. Arrows indicate GT198+ cells. (I) GT198 expression is found in all stages of tumor. (J) Increased GT198 expression is associated with tumor adjacent tissues; (K) with tumors from smokers versus non-smokers; and (L) with tumors from patients with lymph node metastasis. (M) Increased GT198 expression is associated with decreased progression-free survival of oral cancer patients. n, number of cases in analyzed groups. P values are calculated by t test in (I-L) and by log-rank test in (M).