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. 2017 May 25;8(31):51591–51607. doi: 10.18632/oncotarget.18196

Figure 6. GT198+ pericytes give rise to tumor cells in U-251 glioblastoma xenografts.

Figure 6

(A) Immunohistochemical staining of GT198 showing pericyte-specific staining at the periphery of the tumor. Angiogenic area is enlarged in (B) and normal rat brain area in (C). (B) GT198+ pericytes in angiogenic vasculature. Arrows indicate GT198+ pericytes. (C) Normal capillary absence of GT198 expression in rat brain adjacent to tumor. Boxed area is enlarged. (D) Immunofluorescent double staining of GT198 or vWF in red, and VEGF in green, in pericyte-enclosed vessels of different sizes. (E) Immunofluorescent double staining of GT198 in red, and CD133 in green, showing enriched stem cell populations near vessel lumens of the merging vessels. White arrows indicate vessel lumens and a double-positive cell in the enlarged area. Scale bars = 100 μm.