Table 1. Demographic and clinical-pathological characteristics of patients in the study cohort.
Parameter | Status | Total cohort | Basal subset | ||
---|---|---|---|---|---|
Cases | % | Cases | % | ||
Age at diagnosis | ≤35 years | 13 | 3 | 7 | 10 |
>35years | 430 | 97 | 62 | 90 | |
Tumor sizea | T1a/b | 2 | <1 | 1 | <1 |
T1c | 69 | 16 | 7 | 10 | |
T2 | 277 | 63 | 40 | 58 | |
T3 | 66 | 15 | 15 | 22 | |
Unknown | 29 | 7 | 6 | 9 | |
Nodal status | Positive | 190 | 43 | 33 | 48 |
Negative | 228 | 51 | 26 | 38 | |
Unknown | 25 | 6 | 10 | 14 | |
Tumor grade | 1 | 71 | 16 | 4 | 5 |
2 | 267 | 60 | 19 | 28 | |
3 | 103 | 23 | 46 | 67 | |
Unknown | 2 | <1 | 0 | 0 | |
ERb | Positive | 203 | 46 | 0 | 0 |
Negative | 240 | 54 | 69 | 100 | |
Unknown | 0 | 0 | 0 | 0 | |
PRb | Positive | 228 | 51 | 0 | 0 |
Negative | 215 | 49 | 69 | 100 | |
Unknown | 0 | 0 | 0 | 0 | |
Molecular subtypes | Luminal A | 193 | 44 | ||
Luminal B | 48 | 11 | |||
Her2 | 67 | 15 | |||
TNNBc | 35 | 8 | |||
Basal-like | 69 | 15 | |||
Unclassified | 32 | 7 |
aTumor size: 0.1cm<T1a/b<1cm; 1cm ≤ T1c<2cm; 2cm≤T2<5cm; 5cm≤T3.
bER negative defined as <10 fmol/mg protein and PR negative as ≤15 fmol/mg protein (ligand binding assay).
cTNNB: Triple negative-non-basal.