Table 3. Univariate and multivariate analyses of associations between clinical parameters and PD-L1/eCD8 combined status and either relapse free survival or overall survival in the Basal-like subgroup.
| A/Recurrence-free survival | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| Parameter | Comparison | HR (95% CI) | p-value | HR (95% CI) | p-value |
| Age at diagnosis (yrs) | >35 vs ≤35 | 0.95 (0.22-4.14) | 0.947 | 0.26 (0.05-1.47) | 0.127 |
| Tumor size (cm) | >2cm vs ≤2cm | 2.33 (0.79-4.94) | 0.151 | 1.86 (0.50-6.93) | 0.354 |
| Nodal status | pos vs neg | 1.45 (0.64-3.25) | 0.380 | 1.44 (0.54-3.82) | 0.463 |
| Tumor grade | 2 vs 1 | 0.39 (0.10-2.22) | 0.349 | 0.44 (0.05-3.67) | 0.450 |
| 3 vs 1 | 1.86 (0.35-7.69) | 0.536 | 1.18 (0.44-3.21) | 0.743 | |
| PD-L1 + eCD8 expression | Both high vs both low | 0.12 (0.10-0.71) | 0.010 | 0.10 (0.01-0.96) | 0.046 |
| B/Overall survival | Univariate | Multivariate | |||
| Parameter | Comparison | HR (95% CI) | p-value | HR (95% CI) | p-value |
| Age at diagnosis (yrs) | >35 vs ≤35 | 0.96 (0.22-4.14) | 0.954 | 0.13 (0.02-0.91) | 0.040 |
| Tumor size (cm) | >2cm vs ≤2cm | 1.74 (0.66-3.96) | 0.294 | 1.20 (0.36-3.98) | 0.764 |
| Nodal status | pos vs neg | 1.42 (0.65-3.06) | 0.393 | 1.21 (0.47-3.08) | 0.693 |
| Tumor grade | 2 vs 1 | 0.41 (0.10-2.44) | 0.393 | 0.40 (0.05-3.29) | 0.396 |
| 3 vs 1 | 2.08 (0.41-7.50) | 0.459 | 1.12 (0.43-2.92) | 0.824 | |
| PD-L1 + eCD8 expression | Both high vs both low | 0.11 (0.11-0.68) | 0.006 | 0.07 (0.06-0.75) | 0.028 |